Congratulations to Pierre Bourdillon, Cash lab members, and coauthors for their paper on “Differential cortical layer engagement during seizure initiation and spread in humans” in Nature Communications!!! Using past data gathered using the thumbtack laminar arrays of micro-electrodes which has 150 micron spacing between individual contacts which can span cortical layers in the human brain, Bourdillon and coauthors studied seizure activity across cortical layers in patient participants with intractable epilepsy intracranially monitored to identify the seizure onset zone. Ictal (or seizure) activity appeared to come from deeper cortical layers in the seizure onset zone while the same activity showed up in more superficial cortical layers in the seizure propagation zone. This could demonstrate fundamental features of how seizures are generated by underlying microcircuits, with possible clinical diagnostic applications for identifying epileptogenic tissue.
Paper: https://www.nature.com/articles/s41467-024-48746-8
Bourdillon P, Ren L, Halgren M, Paulk AC, Salami P, Ulbert I, Fabó D, King JR, Sjoberg KM, Eskandar EN, Madsen JR, Halgren E, Cash SS. Differential cortical layer engagement during seizure initiation and spread in humans. Nat Commun. 2024 Jun 17;15(1):5153. doi: 10.1038/s41467-024-48746-8. PMID: 38886376; PMCID: PMC11183216.
